Assay Detail
Binding
CHEMBL1936218
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Displacement of [3H]-DPCPX from human adenosine A2B receptor expressed in HEK293 cells after 60 mins
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Pyrrolo- and pyrazolo-[3,4-e][1,2,4]triazolo[1,5-c]pyrimidines as adenosine receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.19 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL332091 | — | — | 1 | 6.70 |
| CHEMBL302765 | — | — | 1 | 5.68 |
| CHEMBL17127 | SCH-58261 | — | 1 | - |
| CHEMBL17121 | SCH-63390 | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL332091 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL302765 | — | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL17127 | SCH-58261 | Ki | > | 10000.0 | nM | - |
| CHEMBL17121 | SCH-63390 | Ki | > | 10000.0 | nM | - |