Assay Detail
Binding
CHEMBL1936474
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of BACE1 using methoxycoumarin-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Lys-dinitrophenyl as substrate preincubated 1 hr before substrate addition measured after 15 mins by FRET assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
A small chemical library of 2-aminoimidazole derivatives as BACE-1 inhibitors: Structure-based design, synthesis, and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.75 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL378225 | — | — | 1 | 8.00 |
| CHEMBL1933457 | — | — | 1 | 5.25 |
| CHEMBL1933459 | — | — | 1 | 5.22 |
| CHEMBL1933456 | — | — | 1 | 5.13 |
| CHEMBL1933455 | — | — | 1 | 5.13 |
| CHEMBL1933453 | — | — | 1 | - |
| CHEMBL1933452 | — | — | 1 | - |
| CHEMBL1933451 | — | — | 1 | - |
| CHEMBL1933450 | — | — | 1 | - |
| CHEMBL1933454 | — | — | 1 | - |
| CHEMBL1933458 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL378225 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1933457 | — | IC50 | = | 5590.0 | nM | 5.25 |
| CHEMBL1933459 | — | IC50 | = | 5950.0 | nM | 5.22 |
| CHEMBL1933456 | — | IC50 | = | 7320.0 | nM | 5.13 |
| CHEMBL1933455 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL1933453 | — | IC50 | - | — | - | |
| CHEMBL1933452 | — | IC50 | - | — | - | |
| CHEMBL1933451 | — | IC50 | - | — | - | |
| CHEMBL1933450 | — | IC50 | - | — | - | |
| CHEMBL1933454 | — | IC50 | - | — | - | |
| CHEMBL1933458 | — | IC50 | - | — | - |