Assay Detail
Binding
CHEMBL1936475
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of BACE1 in chicken primary telencephalon neurons assessed as reduction of amyloid beta38 secretion after 24 hrs by ELISA
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Gallus gallus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
A small chemical library of 2-aminoimidazole derivatives as BACE-1 inhibitors: Structure-based design, synthesis, and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.65 | 4.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1933455 | — | — | 1 | 4.82 |
| CHEMBL1933456 | — | — | 1 | 4.48 |
| CHEMBL1933457 | — | — | 1 | - |
| CHEMBL1933459 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1933455 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL1933456 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL1933457 | — | IC50 | - | — | - | |
| CHEMBL1933459 | — | IC50 | - | — | - |