Assay Detail
Binding
CHEMBL1936639
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]PGD2 from human DP receptor expressed in 293 cells by scintillation counting in presence of 50 % human plasma
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Plasma |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Optimization of phenylacetic acid derivatives for CRTH2 and DP selective antagonism.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.52 | 6.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1933763 | — | — | 1 | 6.68 |
| CHEMBL589973 | — | — | 1 | 6.55 |
| CHEMBL1933762 | — | — | 1 | 6.34 |
| CHEMBL570653 | — | — | 1 | - |
| CHEMBL1933918 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1933763 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL589973 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL1933762 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL570653 | — | IC50 | - | — | - | |
| CHEMBL1933918 | — | IC50 | - | — | - |