Assay Detail
Binding
CHEMBL1936679
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Displacement of [3H]histamine from human H1 receptor expressed in HEK cell membranes
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Ligand based design of novel histamine H₄ receptor antagonists; fragment optimization and analysis of binding kinetics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 5.21 | 5.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1935572 | — | — | 1 | 5.55 |
| CHEMBL1935573 | — | — | 1 | 5.19 |
| CHEMBL1935571 | — | — | 1 | 5.13 |
| CHEMBL1935574 | — | — | 1 | 4.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1935572 | — | Ki | = | 2800.0 | nM | 5.55 |
| CHEMBL1935573 | — | Ki | = | 6422.0 | nM | 5.19 |
| CHEMBL1935571 | — | Ki | = | 7373.0 | nM | 5.13 |
| CHEMBL1935574 | — | Ki | = | 10500.0 | nM | 4.98 |