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Assay Detail

CHEMBL1936809

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Binding
Inhibition of dopamine D2 receptor
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

D(2) dopamine receptor (CHEMBL217)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery and characterization of a potent and selective antagonist of melanin-concentrating hormone receptor 2.
Chen X, Mihalic J, Fan P, Liang L, Lindstrom M, Wong S, Ye Q, Fu Y, Jaen J, Chen JL, Dai K, Li L.
Bioorg Med Chem Lett (2012) 22 : 363 -366
PubMed 22123324 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 2 6.06 6.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1934127 1 6.30
CHEMBL1934130 1 5.82

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1934127 IC50 = 500.0 nM 6.30
CHEMBL1934130 IC50 = 1500.0 nM 5.82