Assay Detail
Functional
CHEMBL1936932
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at human recombinant 5-HT6 receptor expressed human astrocytoma cells assessed as inhibition of 5-HT-induced cAMP accumulation after 1 hr preincubation by HTRF assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel brain penetrant benzofuropiperidine 5-HT₆ receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.77 | 8.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1935590 | — | — | 1 | 8.44 |
| CHEMBL1935599 | — | — | 1 | 8.17 |
| CHEMBL1935589 | — | — | 1 | 8.07 |
| CHEMBL1935601 | — | — | 1 | 8.01 |
| CHEMBL1935594 | — | — | 1 | 7.93 |
| CHEMBL1935592 | — | — | 1 | 7.68 |
| CHEMBL1935600 | — | — | 1 | 7.50 |
| CHEMBL1935593 | — | — | 1 | 7.47 |
| CHEMBL1935597 | — | — | 1 | 7.27 |
| CHEMBL1935595 | — | — | 1 | 7.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1935590 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL1935599 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL1935589 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL1935601 | — | IC50 | = | 9.8 | nM | 8.01 |
| CHEMBL1935594 | — | IC50 | = | 11.7 | nM | 7.93 |
| CHEMBL1935592 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL1935600 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL1935593 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL1935597 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL1935595 | — | IC50 | = | 68.6 | nM | 7.16 |