Assay Detail
Binding
CHEMBL1937035
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human BACE1 assessed as dissociation constant of enzyme-substrate-inhibitor complex using Rh-EVNLDAEFK as substrate by Dixon and Cornish-Bowden plots analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-activity relationships for naturally occurring coumarins as β-secretase inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 5.11 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1078442 | BERGAMOTTIN | — | 1 | 6.16 |
| CHEMBL508648 | BYAKANGELICIN | — | 1 | 5.21 |
| CHEMBL1934195 | — | — | 1 | 4.86 |
| CHEMBL1412710 | — | — | 1 | 4.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1078442 | BERGAMOTTIN | Ki | = | 700.0 | nM | 6.16 |
| CHEMBL508648 | BYAKANGELICIN | Ki | = | 6200.0 | nM | 5.21 |
| CHEMBL1934195 | — | Ki | = | 13700.0 | nM | 4.86 |
| CHEMBL1412710 | — | Ki | = | 61900.0 | nM | 4.21 |