Assay Detail
Binding
CHEMBL1937305
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Inhibition of human recombinant CK2alpha/CK2beta using RRRDDDSDDD peptide as substrate by radiometric assay
38
Total Activities
37
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and SAR of inhibitors of protein kinase CK2: novel tricyclic quinoline analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 8.18 | 9.52 |
| Ki | 1 | 9.66 | 9.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1230165 | SILMITASERTIB | 2.0 | 2 | 9.66 |
| CHEMBL1934184 | — | — | 1 | 9.40 |
| CHEMBL1934182 | — | — | 1 | 9.30 |
| CHEMBL1934181 | — | — | 1 | 9.30 |
| CHEMBL1934172 | — | — | 1 | 9.30 |
| CHEMBL1934180 | — | — | 1 | 9.22 |
| CHEMBL1934318 | — | — | 1 | 9.00 |
| CHEMBL1934166 | — | — | 1 | 9.00 |
| CHEMBL1934160 | — | — | 1 | 8.96 |
| CHEMBL1934173 | — | — | 1 | 8.92 |
| CHEMBL1934164 | — | — | 1 | 8.89 |
| CHEMBL1934319 | — | — | 1 | 8.68 |
| CHEMBL1934165 | — | — | 1 | 8.57 |
| CHEMBL1934163 | — | — | 1 | 8.54 |
| CHEMBL1934171 | — | — | 1 | 8.46 |
| CHEMBL1934178 | — | — | 1 | 8.46 |
| CHEMBL1934193 | — | — | 1 | 8.43 |
| CHEMBL1934183 | — | — | 1 | 8.38 |
| CHEMBL1934168 | — | — | 1 | 8.24 |
| CHEMBL1934192 | — | — | 1 | 8.05 |
| CHEMBL1934170 | — | — | 1 | 7.96 |
| CHEMBL1934177 | — | — | 1 | 7.92 |
| CHEMBL1934169 | — | — | 1 | 7.89 |
| CHEMBL1934176 | — | — | 1 | 7.82 |
| CHEMBL1934179 | — | — | 1 | 7.77 |
| CHEMBL1934174 | — | — | 1 | 7.70 |
| CHEMBL1934189 | — | — | 1 | 7.70 |
| CHEMBL1934186 | — | — | 1 | 7.52 |
| CHEMBL1934167 | — | — | 1 | 7.47 |
| CHEMBL1934162 | — | — | 1 | 7.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1230165 | SILMITASERTIB | Ki | = | 0.22 | nM | 9.66 |
| CHEMBL1230165 | SILMITASERTIB | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL1934184 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL1934182 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL1934181 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL1934172 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL1934180 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL1934166 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1934318 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1934160 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL1934173 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL1934164 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL1934319 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL1934165 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL1934163 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL1934171 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL1934178 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL1934193 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL1934183 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL1934168 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL1934192 | — | IC50 | = | 8.9 | nM | 8.05 |
| CHEMBL1934170 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL1934177 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1934169 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1934176 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL1934179 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL1934189 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1934174 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1934186 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1934167 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL1934162 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL1934175 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL1934190 | — | IC50 | = | 164.0 | nM | 6.79 |
| CHEMBL1934185 | — | IC50 | = | 395.0 | nM | 6.40 |
| CHEMBL1934187 | — | IC50 | = | 444.0 | nM | 6.35 |
| CHEMBL1934191 | — | IC50 | = | 2025.0 | nM | 5.69 |
| CHEMBL1934188 | — | IC50 | > | 2500.0 | nM | - |
| CHEMBL1934161 | — | IC50 | > | 2500.0 | nM | - |