Assay Detail
Binding
CHEMBL1937507
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Inhibition of human MMP-12
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of potent and selective matrix metalloprotease 12 inhibitors for the potential treatment of chronic obstructive pulmonary disease (COPD).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 8.73 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1935286 | — | — | 1 | 10.00 |
| CHEMBL1935285 | — | — | 1 | 10.00 |
| CHEMBL1935287 | — | — | 1 | 9.70 |
| CHEMBL1935288 | — | — | 1 | 9.70 |
| CHEMBL1935304 | — | — | 1 | 9.52 |
| CHEMBL1935290 | — | — | 1 | 9.40 |
| CHEMBL1935284 | — | — | 1 | 9.40 |
| CHEMBL1935280 | — | — | 1 | 9.15 |
| CHEMBL1935291 | — | — | 1 | 9.00 |
| CHEMBL1935292 | — | — | 1 | 8.92 |
| CHEMBL1935300 | — | — | 1 | 8.80 |
| CHEMBL1935298 | — | — | 1 | 8.72 |
| CHEMBL550038 | — | — | 1 | 8.70 |
| CHEMBL1935283 | — | — | 1 | 8.66 |
| CHEMBL1935299 | — | — | 1 | 8.66 |
| CHEMBL1935301 | — | — | 1 | 8.64 |
| CHEMBL1935294 | — | — | 1 | 8.54 |
| CHEMBL1935303 | — | — | 1 | 8.40 |
| CHEMBL1935295 | — | — | 1 | 8.35 |
| CHEMBL1935297 | — | — | 1 | 8.27 |
| CHEMBL1935302 | — | — | 1 | 8.14 |
| CHEMBL1935293 | — | — | 1 | 8.07 |
| CHEMBL1935278 | — | — | 1 | 7.89 |
| CHEMBL1935279 | — | — | 1 | 7.82 |
| CHEMBL1935296 | — | — | 1 | 7.77 |
| CHEMBL1935282 | — | — | 1 | 7.75 |
| CHEMBL1935281 | — | — | 1 | 7.64 |
| CHEMBL1935289 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1935286 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL1935285 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL1935287 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL1935288 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL1935304 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL1935290 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL1935284 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL1935280 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL1935291 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1935292 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL1935300 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL1935298 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL550038 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1935283 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL1935299 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL1935301 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL1935294 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL1935303 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1935295 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL1935297 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL1935302 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL1935293 | — | IC50 | = | 8.6 | nM | 8.07 |
| CHEMBL1935278 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1935279 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL1935296 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL1935282 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1935281 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL1935289 | — | IC50 | < | 1.0 | nM | - |