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Assay Detail

CHEMBL1937523

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of sheep MMP-12
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Ovis aries
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Discovery of potent and selective matrix metalloprotease 12 inhibitors for the potential treatment of chronic obstructive pulmonary disease (COPD).
Wu Y, Li J, Wu J, Morgan P, Xu X, Rancati F, Vallese S, Raveglia L, Hotchandani R, Fuller N, Bard J, Cunningham K, Fish S, Krykbaev R, Tam S, Goldman SJ, Williams C, Mansour TS, Saiah E, Sypek J, Li W.
Bioorg Med Chem Lett (2012) 22 : 138 -143
PubMed 22153340 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 8.27 8.27

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1935291 1 8.27

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1935291 IC50 = 5.4 nM 8.27