Assay Detail
Functional
CHEMBL1937692
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human MCF7 cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery and bioactivity of 4-(2-arylpyrido[3',2':3,4]pyrrolo[1,2-f][1,2,4]triazin-4-yl) morpholine derivatives as novel PI3K inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.85 | 5.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1934303 | — | — | 1 | 5.21 |
| CHEMBL1934304 | — | — | 1 | 5.14 |
| CHEMBL1934306 | — | — | 1 | 4.89 |
| CHEMBL1934301 | — | — | 1 | 4.84 |
| CHEMBL1934305 | — | — | 1 | 4.82 |
| CHEMBL1934302 | — | — | 1 | 4.73 |
| CHEMBL1934307 | — | — | 1 | 4.70 |
| CHEMBL573339 | PI-103 | — | 1 | 4.65 |
| CHEMBL1934300 | — | — | 1 | 4.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1934303 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL1934304 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL1934306 | — | IC50 | = | 12800.0 | nM | 4.89 |
| CHEMBL1934301 | — | IC50 | = | 14400.0 | nM | 4.84 |
| CHEMBL1934305 | — | IC50 | = | 15300.0 | nM | 4.82 |
| CHEMBL1934302 | — | IC50 | = | 18700.0 | nM | 4.73 |
| CHEMBL1934307 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL573339 | PI-103 | IC50 | = | 22400.0 | nM | 4.65 |
| CHEMBL1934300 | — | IC50 | = | 22700.0 | nM | 4.64 |