Assay Detail
Functional
CHEMBL1937693
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Antiproliferative activity against human HT-29 cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery and bioactivity of 4-(2-arylpyrido[3',2':3,4]pyrrolo[1,2-f][1,2,4]triazin-4-yl) morpholine derivatives as novel PI3K inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.59 | 4.79 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1934303 | — | — | 1 | 4.79 |
| CHEMBL1934306 | — | — | 1 | 4.67 |
| CHEMBL1934300 | — | — | 1 | 4.65 |
| CHEMBL1934307 | — | — | 1 | 4.55 |
| CHEMBL1934302 | — | — | 1 | 4.52 |
| CHEMBL1934305 | — | — | 1 | 4.52 |
| CHEMBL1934304 | — | — | 1 | 4.43 |
| CHEMBL1934301 | — | — | 1 | - |
| CHEMBL573339 | PI-103 | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1934303 | — | IC50 | = | 16400.0 | nM | 4.79 |
| CHEMBL1934306 | — | IC50 | = | 21600.0 | nM | 4.67 |
| CHEMBL1934300 | — | IC50 | = | 22300.0 | nM | 4.65 |
| CHEMBL1934307 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL1934302 | — | IC50 | = | 30400.0 | nM | 4.52 |
| CHEMBL1934305 | — | IC50 | = | 29900.0 | nM | 4.52 |
| CHEMBL1934304 | — | IC50 | = | 37500.0 | nM | 4.43 |
| CHEMBL1934301 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL573339 | PI-103 | IC50 | > | 50000.0 | nM | - |