Assay Detail
Binding
CHEMBL1938102
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Inhibition of human recombinant His-tagged Tip60 expressed in Escherichia coli BL21(DE3) cells using [14C]Ac-AoA and histone H4 as substrate after 5 mins by scintillation counting
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
6-alkylsalicylates are selective Tip60 inhibitors and target the acetyl-CoA binding site.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 4.16 | 4.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL455368 | ANACARDIC ACID | — | 1 | 4.19 |
| CHEMBL1215739 | — | — | 1 | 4.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL455368 | ANACARDIC ACID | IC50 | = | 64000.0 | nM | 4.19 |
| CHEMBL1215739 | — | IC50 | = | 74000.0 | nM | 4.13 |