Assay Detail
Functional
CHEMBL1941433
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Antiviral activity against Human coxsackievirus B5 Ohio-1 infected in african green monkey Vero 76 cells assessed as reduction of virus-induced plaque formation after 3 days using crystal violet staining
44
Total Activities
44
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Coxsackievirus B5 |
| Cell Type | Vero |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Quinoline tricyclic derivatives. Design, synthesis and evaluation of the antiviral activity of three new classes of RNA-dependent RNA polymerase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 44 | 4.51 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1940457 | — | — | 1 | 5.52 |
| CHEMBL1940461 | — | — | 1 | 4.85 |
| CHEMBL1940448 | — | — | 1 | 4.72 |
| CHEMBL98778 | 2'-ETHYNYL-D-CYTIDINE | — | 1 | 4.57 |
| CHEMBL1940451 | — | — | 1 | 4.46 |
| CHEMBL1940449 | — | — | 1 | 4.44 |
| CHEMBL1940459 | — | — | 1 | 4.37 |
| CHEMBL1940450 | — | — | 1 | 4.37 |
| CHEMBL1940455 | — | — | 1 | 4.33 |
| CHEMBL1940463 | — | — | 1 | 4.30 |
| CHEMBL1940453 | — | — | 1 | 4.11 |
| CHEMBL583179 | — | — | 1 | 4.07 |
| CHEMBL1940438 | — | — | 1 | - |
| CHEMBL1940437 | — | — | 1 | - |
| CHEMBL1940445 | — | — | 1 | - |
| CHEMBL573016 | — | — | 1 | - |
| CHEMBL1940475 | — | — | 1 | - |
| CHEMBL1940474 | — | — | 1 | - |
| CHEMBL1940473 | — | — | 1 | - |
| CHEMBL1940472 | — | — | 1 | - |
| CHEMBL1940471 | — | — | 1 | - |
| CHEMBL1940470 | — | — | 1 | - |
| CHEMBL1940469 | — | — | 1 | - |
| CHEMBL1940468 | — | — | 1 | - |
| CHEMBL1940467 | — | — | 1 | - |
| CHEMBL1940476 | — | — | 1 | - |
| CHEMBL1940465 | — | — | 1 | - |
| CHEMBL1940464 | — | — | 1 | - |
| CHEMBL1940462 | — | — | 1 | - |
| CHEMBL1940466 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1940457 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL1940461 | — | EC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL1940448 | — | EC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL98778 | 2'-ETHYNYL-D-CYTIDINE | EC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL1940451 | — | EC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL1940449 | — | EC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL1940459 | — | EC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL1940450 | — | EC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL1940455 | — | EC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL1940463 | — | EC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL1940453 | — | EC50 | = | 78000.0 | nM | 4.11 |
| CHEMBL583179 | — | EC50 | = | 86000.0 | nM | 4.07 |
| CHEMBL1940437 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1940458 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1940438 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1940439 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1940440 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1940441 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1940442 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1940443 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1940444 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1940460 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1938417 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1940446 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1940447 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1940452 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1940454 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1940456 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1940445 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL573016 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1940475 | — | EC50 | > | 88000.0 | nM | - |
| CHEMBL1940474 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1940473 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1940472 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1940471 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1940470 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1940469 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1940468 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1940467 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1940476 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1940465 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1940464 | — | EC50 | > | 90000.0 | nM | - |
| CHEMBL1940462 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1940466 | — | EC50 | > | 100000.0 | nM | - |