Assay Detail
Functional
CHEMBL1941434
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against Human poliovirus 1 strain Sabin Chat infected in african green monkey Vero 76 cells assessed as virus-induced reduction of plaque formation after 2 days using crystal violet staining
44
Total Activities
44
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human poliovirus 1 strain Sabin |
| Cell Type | Vero |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Quinoline tricyclic derivatives. Design, synthesis and evaluation of the antiviral activity of three new classes of RNA-dependent RNA polymerase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 44 | 4.36 | 4.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL98778 | 2'-ETHYNYL-D-CYTIDINE | — | 1 | 4.64 |
| CHEMBL1940448 | — | — | 1 | 4.43 |
| CHEMBL1940449 | — | — | 1 | 4.28 |
| CHEMBL1940459 | — | — | 1 | 4.10 |
| CHEMBL1940470 | — | — | 1 | - |
| CHEMBL1940441 | — | — | 1 | - |
| CHEMBL1940471 | — | — | 1 | - |
| CHEMBL1940472 | — | — | 1 | - |
| CHEMBL1940473 | — | — | 1 | - |
| CHEMBL1940474 | — | — | 1 | - |
| CHEMBL1940475 | — | — | 1 | - |
| CHEMBL1940476 | — | — | 1 | - |
| CHEMBL1940445 | — | — | 1 | - |
| CHEMBL1940437 | — | — | 1 | - |
| CHEMBL1940438 | — | — | 1 | - |
| CHEMBL1940439 | — | — | 1 | - |
| CHEMBL1940440 | — | — | 1 | - |
| CHEMBL1940469 | — | — | 1 | - |
| CHEMBL1940468 | — | — | 1 | - |
| CHEMBL1940467 | — | — | 1 | - |
| CHEMBL1940466 | — | — | 1 | - |
| CHEMBL1940465 | — | — | 1 | - |
| CHEMBL1940464 | — | — | 1 | - |
| CHEMBL1940463 | — | — | 1 | - |
| CHEMBL1940462 | — | — | 1 | - |
| CHEMBL1940461 | — | — | 1 | - |
| CHEMBL1940460 | — | — | 1 | - |
| CHEMBL1940458 | — | — | 1 | - |
| CHEMBL1940455 | — | — | 1 | - |
| CHEMBL1940457 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL98778 | 2'-ETHYNYL-D-CYTIDINE | EC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL1940448 | — | EC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL1940449 | — | EC50 | = | 53000.0 | nM | 4.28 |
| CHEMBL1940459 | — | EC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL1940445 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL573016 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1940437 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1940438 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1940439 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1940440 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1940441 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1940442 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1940443 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1940444 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL583179 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1940456 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1938417 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1940446 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1940447 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1940450 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1940451 | — | EC50 | > | 95000.0 | nM | - |
| CHEMBL1940452 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1940453 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1940454 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1940466 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1940457 | — | EC50 | > | 80000.0 | nM | - |
| CHEMBL1940455 | — | EC50 | > | 75000.0 | nM | - |
| CHEMBL1940458 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1940460 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1940461 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1940462 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1940463 | — | EC50 | > | 90000.0 | nM | - |
| CHEMBL1940464 | — | EC50 | > | 90000.0 | nM | - |
| CHEMBL1940465 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1940476 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1940467 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1940468 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1940469 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1940470 | — | EC50 | >= | 100000.0 | nM | - |
| CHEMBL1940471 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1940472 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1940473 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1940474 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1940475 | — | EC50 | > | 88000.0 | nM | - |