Assay Detail
Binding
CHEMBL1941823
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant CA9 after 6 hrs by stopped flow CO2 hydration assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Glycosyl coumarin carbonic anhydrase IX and XII inhibitors strongly attenuate the growth of primary breast tumors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 6.31 | 8.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1172750 | — | — | 1 | 8.04 |
| CHEMBL1393422 | — | — | 1 | 7.03 |
| CHEMBL1938469 | — | — | 1 | 6.70 |
| CHEMBL1938471 | — | — | 1 | 6.46 |
| CHEMBL1441570 | — | — | 1 | 6.43 |
| CHEMBL51628 | UMBELLIFERONE | — | 1 | 6.32 |
| CHEMBL12208 | HYMECROMONE | 2.0 | 1 | 6.25 |
| CHEMBL1938472 | — | — | 1 | 6.09 |
| CHEMBL1938470 | — | — | 1 | 5.50 |
| CHEMBL1938473 | — | — | 1 | 4.26 |
| CHEMBL6466 | COUMARIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1172750 | — | Ki | = | 9.2 | nM | 8.04 |
| CHEMBL1393422 | — | Ki | = | 93.0 | nM | 7.03 |
| CHEMBL1938469 | — | Ki | = | 201.0 | nM | 6.70 |
| CHEMBL1938471 | — | Ki | = | 350.0 | nM | 6.46 |
| CHEMBL1441570 | — | Ki | = | 370.0 | nM | 6.43 |
| CHEMBL51628 | UMBELLIFERONE | Ki | = | 478.0 | nM | 6.32 |
| CHEMBL12208 | HYMECROMONE | Ki | = | 560.0 | nM | 6.25 |
| CHEMBL1938472 | — | Ki | = | 820.0 | nM | 6.09 |
| CHEMBL1938470 | — | Ki | = | 3200.0 | nM | 5.50 |
| CHEMBL1938473 | — | Ki | = | 54500.0 | nM | 4.26 |
| CHEMBL6466 | COUMARIN | Ki | > | 500000.0 | nM | - |