Assay Detail
Binding
CHEMBL1941824
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Inhibition of human recombinant CA12 after 6 hrs by stopped flow CO2 hydration assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Glycosyl coumarin carbonic anhydrase IX and XII inhibitors strongly attenuate the growth of primary breast tumors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 6.62 | 8.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1393422 | — | — | 1 | 8.07 |
| CHEMBL1172750 | — | — | 1 | 7.37 |
| CHEMBL1938470 | — | — | 1 | 7.28 |
| CHEMBL1441570 | — | — | 1 | 7.27 |
| CHEMBL1938472 | — | — | 1 | 7.00 |
| CHEMBL1938471 | — | — | 1 | 6.98 |
| CHEMBL1938469 | — | — | 1 | 6.74 |
| CHEMBL51628 | UMBELLIFERONE | — | 1 | 6.12 |
| CHEMBL12208 | HYMECROMONE | 2.0 | 1 | 5.09 |
| CHEMBL1938473 | — | — | 1 | 4.31 |
| CHEMBL6466 | COUMARIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1393422 | — | Ki | = | 8.5 | nM | 8.07 |
| CHEMBL1172750 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL1938470 | — | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL1441570 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL1938472 | — | Ki | = | 101.0 | nM | 7.00 |
| CHEMBL1938471 | — | Ki | = | 105.0 | nM | 6.98 |
| CHEMBL1938469 | — | Ki | = | 184.0 | nM | 6.74 |
| CHEMBL51628 | UMBELLIFERONE | Ki | = | 754.0 | nM | 6.12 |
| CHEMBL12208 | HYMECROMONE | Ki | = | 8100.0 | nM | 5.09 |
| CHEMBL1938473 | — | Ki | = | 48600.0 | nM | 4.31 |
| CHEMBL6466 | COUMARIN | Ki | > | 500000.0 | nM | - |