Assay Detail
Binding
CHEMBL1942013
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Mycobacterium tuberculosis RmlD assessed as inhibition of dTDP-beta-6-deoxy-L-lyxo-4-hexulose to dTDP-beta-L-rhamnose conversion
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mycobacterium tuberculosis |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
dTDP-4-dehydrorhamnose reductase (CHEMBL1938225) ↗| Type | SINGLE PROTEIN |
| Organism | Mycobacterium tuberculosis |
Publication
Novel inhibitors of Mycobacterium tuberculosis dTDP-6-deoxy-L-lyxo-4-hexulose reductase (RmlD) identified by virtual screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.29 | 6.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL375328 | — | — | 1 | 6.05 |
| CHEMBL1451216 | — | — | 1 | 5.68 |
| CHEMBL175266 | — | — | 1 | 4.82 |
| CHEMBL205119 | EFFUSOL | — | 1 | 4.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL375328 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL1451216 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL175266 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL205119 | EFFUSOL | IC50 | = | 25000.0 | nM | 4.60 |