Assay Detail
Binding
CHEMBL1942018
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Inhibition of MMP3 using Mca-Arg-Pro-Lys-Pro-Val-Glu-Nva-Trp-Arg-Lys(Dnp)-NH2 as substrate preincubated for 4 hrs measured every 15 secs for 20 mins by fluorescence analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Novel 1-hydroxypiperazine-2,6-diones as new leads in the inhibition of metalloproteinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.70 | 8.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL515980 | — | — | 1 | 8.17 |
| CHEMBL514138 | CGS-27023A | — | 1 | 7.80 |
| CHEMBL1939846 | — | — | 1 | 6.66 |
| CHEMBL1939844 | — | — | 1 | 5.47 |
| CHEMBL1939845 | — | — | 1 | 5.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL515980 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL514138 | CGS-27023A | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL1939846 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL1939844 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL1939845 | — | IC50 | = | 3900.0 | nM | 5.41 |