Assay Detail
Binding
CHEMBL1942020
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Inhibition of human recombinant MMP8 using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate preincubated for 4 hrs measured every 15 secs for 20 mins by fluorescence analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel 1-hydroxypiperazine-2,6-diones as new leads in the inhibition of metalloproteinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.12 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1939846 | — | — | 1 | 7.68 |
| CHEMBL1939845 | — | — | 1 | 7.17 |
| CHEMBL1939844 | — | — | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1939846 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL1939845 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL1939844 | — | IC50 | = | 300.0 | nM | 6.52 |