Assay Detail
Functional
CHEMBL1942166
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Antiproliferative activity against human A549 cells after 72 hrs by resazurin reduction assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of novel, potent, and selective inhibitors of 3-phosphoinositide-dependent kinase (PDK1).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 5.56 | 5.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1940251 | — | — | 1 | 5.75 |
| CHEMBL1940252 | — | — | 1 | 5.66 |
| CHEMBL1940253 | — | — | 1 | 5.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1940251 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL1940252 | — | EC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL1940253 | — | EC50 | = | 5200.0 | nM | 5.28 |