Assay Detail
Binding
CHEMBL1942167
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PDK1-mediated AKT1 phosphorylation at T308 in human H460 cells after 2 hrs by ELISA
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | H460 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
3-phosphoinositide-dependent protein kinase 1 (CHEMBL2534) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of novel, potent, and selective inhibitors of 3-phosphoinositide-dependent kinase (PDK1).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.74 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1940251 | — | — | 1 | 6.92 |
| CHEMBL1940252 | — | — | 1 | 6.80 |
| CHEMBL1940253 | — | — | 1 | 6.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1940251 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL1940252 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL1940253 | — | IC50 | = | 320.0 | nM | 6.50 |