Assay Detail
Functional
CHEMBL1942689
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Antiproliferative activity against human KARPAS299 cells after 96 hrs by cell counting assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KARPAS-299 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and synthesis of a highly selective, orally active and potent anaplastic lymphoma kinase inhibitor (CH5424802).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.48 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1738797 | ALECTINIB | 4.0 | 1 | 8.52 |
| CHEMBL1940181 | — | — | 1 | 8.32 |
| CHEMBL1823221 | — | — | 1 | 7.89 |
| CHEMBL1940179 | — | — | 1 | 7.65 |
| CHEMBL1940182 | — | — | 1 | 7.58 |
| CHEMBL1940180 | — | — | 1 | 7.58 |
| CHEMBL1940178 | — | — | 1 | 7.34 |
| CHEMBL1940175 | — | — | 1 | 7.06 |
| CHEMBL1940174 | — | — | 1 | 6.92 |
| CHEMBL1940177 | — | — | 1 | 6.82 |
| CHEMBL1940176 | — | — | 1 | 6.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1738797 | ALECTINIB | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1940181 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL1823221 | — | IC50 | = | 12.8 | nM | 7.89 |
| CHEMBL1940179 | — | IC50 | = | 22.4 | nM | 7.65 |
| CHEMBL1940182 | — | IC50 | = | 26.1 | nM | 7.58 |
| CHEMBL1940180 | — | IC50 | = | 26.5 | nM | 7.58 |
| CHEMBL1940178 | — | IC50 | = | 45.8 | nM | 7.34 |
| CHEMBL1940175 | — | IC50 | = | 86.9 | nM | 7.06 |
| CHEMBL1940174 | — | IC50 | = | 121.0 | nM | 6.92 |
| CHEMBL1940177 | — | IC50 | = | 151.0 | nM | 6.82 |
| CHEMBL1940176 | — | IC50 | = | 238.0 | nM | 6.62 |