Assay Detail

CHEMBL1943640

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Binding

Binding affinity to human histamine H4 receptor

ChEMBL ↗

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Target

Histamine H4 receptor (CHEMBL3759) ↗

Open DB target context

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Primary target Histamine H4 receptor

CHEMBL3759

Anchored from Assay target.

Protein identity Histamine H4 receptor

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Histamine H4 receptor (CHEMBL3759) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Synthesis of novel histamine H4 receptor antagonists.

Lane CA, Hay D, Mowbray CE, Paradowski M, Selby MD, Swain NA, Williams DH.
Bioorg Med Chem Lett (2012) 22 : 1156 -1159
PubMed 22189138 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	1	8.40	8.40

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL129198	JNJ-7777120	—	1	8.40

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL129198	JNJ-7777120	Ki	=	4.0	nM	8.40