Assay Detail
Binding
CHEMBL1944296
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Inhibition of Plasmodium falciparum falcipain-2 using Z-Leu-Arg-AMC as substrate after 30 mins by spectrophotometric assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design and synthesis of small molecular dual inhibitor of falcipain-2 and dihydrofolate reductase as antimalarial agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.35 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL374508 | E-64 | — | 1 | 7.77 |
| CHEMBL1939235 | — | — | 1 | 5.57 |
| CHEMBL1939368 | — | — | 1 | 5.16 |
| CHEMBL1939232 | — | — | 1 | 5.09 |
| CHEMBL1939229 | — | — | 1 | 5.05 |
| CHEMBL1939367 | — | — | 1 | 5.01 |
| CHEMBL1939228 | — | — | 1 | 4.88 |
| CHEMBL549325 | — | — | 1 | 4.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL374508 | E-64 | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL1939235 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL1939368 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL1939232 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL1939229 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL1939367 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL1939228 | — | IC50 | = | 13200.0 | nM | 4.88 |
| CHEMBL549325 | — | IC50 | = | 54200.0 | nM | 4.27 |