Assay Detail
Binding
CHEMBL1944297
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Inhibition of Plasmodium falciparum DHFR assessed as oxidation of NADPH to NADP+ after 15 mins spectrophotometric assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design and synthesis of small molecular dual inhibitor of falcipain-2 and dihydrofolate reductase as antimalarial agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.22 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL36 | PYRIMETHAMINE | 4.0 | 1 | 7.70 |
| CHEMBL1939367 | — | — | 1 | 5.75 |
| CHEMBL1939223 | — | — | 1 | 5.30 |
| CHEMBL1939368 | — | — | 1 | 5.20 |
| CHEMBL1939233 | — | — | 1 | 5.03 |
| CHEMBL1939234 | — | — | 1 | 4.90 |
| CHEMBL1939235 | — | — | 1 | 4.84 |
| CHEMBL1939229 | — | — | 1 | 4.82 |
| CHEMBL1939228 | — | — | 1 | 4.78 |
| CHEMBL1939232 | — | — | 1 | 4.70 |
| CHEMBL549325 | — | — | 1 | 4.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL36 | PYRIMETHAMINE | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1939367 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL1939223 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL1939368 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL1939233 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL1939234 | — | IC50 | = | 12600.0 | nM | 4.90 |
| CHEMBL1939235 | — | IC50 | = | 14600.0 | nM | 4.84 |
| CHEMBL1939229 | — | IC50 | = | 15100.0 | nM | 4.82 |
| CHEMBL1939228 | — | IC50 | = | 16800.0 | nM | 4.78 |
| CHEMBL1939232 | — | IC50 | = | 19800.0 | nM | 4.70 |
| CHEMBL549325 | — | IC50 | = | 35500.0 | nM | 4.45 |