Assay Detail
Functional
CHEMBL1944480
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiinflammatory activity in LPS-stimulated human isolated PBMC assessed as inhibition of TNFalpha production preincubated for 1 hr prior to LPS-challenge by ELISA
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PBMC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and synthesis of inhaled p38 inhibitors for the treatment of chronic obstructive pulmonary disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 8.45 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1938753 | — | — | 1 | 9.10 |
| CHEMBL1938745 | — | — | 1 | 9.10 |
| CHEMBL1938743 | — | — | 1 | 9.10 |
| CHEMBL1938736 | — | — | 1 | 9.10 |
| CHEMBL1938744 | — | — | 1 | 9.10 |
| CHEMBL1938739 | — | — | 1 | 8.96 |
| CHEMBL1938747 | — | — | 1 | 8.96 |
| CHEMBL1938751 | — | — | 1 | 8.92 |
| CHEMBL1938740 | — | — | 1 | 8.85 |
| CHEMBL1938761 | — | — | 1 | 8.82 |
| CHEMBL1938749 | — | — | 1 | 8.82 |
| CHEMBL1938400 | PF-03715455 | 2.0 | 1 | 8.77 |
| CHEMBL1938750 | — | — | 1 | 8.77 |
| CHEMBL1938754 | — | — | 1 | 8.74 |
| CHEMBL1938755 | — | — | 1 | 8.72 |
| CHEMBL1938758 | — | — | 1 | 8.72 |
| CHEMBL1938737 | — | — | 1 | 8.70 |
| CHEMBL1938741 | — | — | 1 | 8.70 |
| CHEMBL1938756 | — | — | 1 | 8.60 |
| CHEMBL1938746 | — | — | 1 | 8.57 |
| CHEMBL1938757 | — | — | 1 | 8.46 |
| CHEMBL1938762 | — | — | 1 | 8.24 |
| CHEMBL1938738 | — | — | 1 | 8.17 |
| CHEMBL1938752 | — | — | 1 | 7.97 |
| CHEMBL1938759 | — | — | 1 | 7.97 |
| CHEMBL103667 | DORAMAPIMOD | 2.0 | 1 | 7.82 |
| CHEMBL1938760 | — | — | 1 | 7.66 |
| CHEMBL1938763 | — | — | 1 | 7.40 |
| CHEMBL1938764 | — | — | 1 | 7.24 |
| CHEMBL1938742 | — | — | 1 | 7.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1938753 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL1938745 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL1938743 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL1938736 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL1938744 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL1938739 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL1938747 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL1938751 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL1938740 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL1938761 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL1938749 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL1938400 | PF-03715455 | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL1938750 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL1938754 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL1938755 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL1938758 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL1938737 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1938741 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1938756 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL1938746 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL1938757 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL1938762 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL1938738 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL1938752 | — | IC50 | = | 10.6 | nM | 7.97 |
| CHEMBL1938759 | — | IC50 | = | 10.6 | nM | 7.97 |
| CHEMBL103667 | DORAMAPIMOD | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL1938760 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL1938763 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1938764 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL1938742 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL1938748 | — | IC50 | = | 155.0 | nM | 6.81 |