Assay Detail
Binding
CHEMBL1947347
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Inhibition of rat recombinant nNOS expressed in baculovirus-infected Sf9 cells assessed as conversion of oxyhemoglobin to methemoglobin by UV spectrophotometer analysis
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel inhibitors of nitric oxide synthase with antioxidant properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 30 | 4.38 | 4.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1529996 | — | — | 1 | 4.90 |
| CHEMBL1946353 | — | — | 1 | 4.86 |
| CHEMBL1946359 | — | — | 1 | 4.65 |
| CHEMBL1946356 | — | — | 1 | 4.65 |
| CHEMBL1946354 | — | — | 1 | 4.50 |
| CHEMBL1946357 | — | — | 1 | 4.49 |
| CHEMBL1946355 | — | — | 1 | 4.45 |
| CHEMBL1946204 | — | — | 1 | 4.44 |
| CHEMBL1945914 | — | — | 1 | 4.40 |
| CHEMBL1945915 | — | — | 1 | 4.40 |
| CHEMBL1946206 | — | — | 1 | 4.40 |
| CHEMBL1945916 | — | — | 1 | 4.35 |
| CHEMBL1946352 | — | — | 1 | 4.33 |
| CHEMBL1946351 | — | — | 1 | 4.32 |
| CHEMBL1946207 | — | — | 1 | 4.20 |
| CHEMBL1946208 | — | — | 1 | 4.19 |
| CHEMBL1946358 | — | — | 1 | 4.18 |
| CHEMBL447987 | — | — | 1 | 4.13 |
| CHEMBL1946203 | — | — | 1 | 4.12 |
| CHEMBL1945752 | — | — | 1 | 4.07 |
| CHEMBL1945753 | — | — | 1 | 4.05 |
| CHEMBL1945917 | — | — | 1 | - |
| CHEMBL1946205 | — | — | 1 | - |
| CHEMBL1548634 | — | — | 1 | - |
| CHEMBL162549 | — | — | 1 | - |
| CHEMBL1945755 | — | — | 1 | - |
| CHEMBL1945754 | — | — | 1 | - |
| CHEMBL1945751 | — | — | 1 | - |
| CHEMBL1945750 | — | — | 1 | - |
| CHEMBL1945749 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1529996 | — | Ki | = | 12500.0 | nM | 4.90 |
| CHEMBL1946353 | — | Ki | = | 13750.0 | nM | 4.86 |
| CHEMBL1946359 | — | Ki | = | 22500.0 | nM | 4.65 |
| CHEMBL1946356 | — | Ki | = | 22500.0 | nM | 4.65 |
| CHEMBL1946354 | — | Ki | = | 31660.0 | nM | 4.50 |
| CHEMBL1946357 | — | Ki | = | 32500.0 | nM | 4.49 |
| CHEMBL1946355 | — | Ki | = | 35830.0 | nM | 4.45 |
| CHEMBL1946204 | — | Ki | = | 36250.0 | nM | 4.44 |
| CHEMBL1945914 | — | Ki | = | 40000.0 | nM | 4.40 |
| CHEMBL1945915 | — | Ki | = | 40000.0 | nM | 4.40 |
| CHEMBL1946206 | — | Ki | = | 40000.0 | nM | 4.40 |
| CHEMBL1945916 | — | Ki | = | 45000.0 | nM | 4.35 |
| CHEMBL1946352 | — | Ki | = | 46600.0 | nM | 4.33 |
| CHEMBL1946351 | — | Ki | = | 47500.0 | nM | 4.32 |
| CHEMBL1946207 | — | Ki | = | 63000.0 | nM | 4.20 |
| CHEMBL1946208 | — | Ki | = | 65000.0 | nM | 4.19 |
| CHEMBL1946358 | — | Ki | = | 66250.0 | nM | 4.18 |
| CHEMBL447987 | — | Ki | = | 74000.0 | nM | 4.13 |
| CHEMBL1946203 | — | Ki | = | 75000.0 | nM | 4.12 |
| CHEMBL1945752 | — | Ki | = | 85000.0 | nM | 4.07 |
| CHEMBL1945753 | — | Ki | = | 90000.0 | nM | 4.05 |
| CHEMBL1945917 | — | Ki | = | 120000.0 | nM | - |
| CHEMBL1946205 | — | Ki | = | 230000.0 | nM | - |
| CHEMBL1548634 | — | Ki | = | 480000.0 | nM | - |
| CHEMBL162549 | — | Ki | = | 105000.0 | nM | - |
| CHEMBL1945755 | — | Ki | = | 450000.0 | nM | - |
| CHEMBL1945754 | — | Ki | = | 750000.0 | nM | - |
| CHEMBL1945751 | — | Ki | = | 620000.0 | nM | - |
| CHEMBL1945750 | — | Ki | > | 500000.0 | nM | - |
| CHEMBL1945749 | — | Ki | = | 450000.0 | nM | - |