Assay Detail
Binding
CHEMBL1947439
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Inhibition of GST-tagged astrosclera willeyana Astrosclerin-3 expressed in Escherichia coli after 15 mins preincubation by stopped flow CO2 hydration assay
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Astrosclera willeyana |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Cloning, characterization and sulfonamide inhibition studies of an α-carbonic anhydrase from the living fossil sponge Astrosclera willeyana.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 42 | 6.45 | 8.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL71611 | — | — | 1 | 8.55 |
| CHEMBL268439 | — | — | 1 | 8.41 |
| CHEMBL7146 | — | — | 1 | 7.80 |
| CHEMBL73962 | BENZOLAMIDE | — | 1 | 7.50 |
| CHEMBL51668 | — | — | 1 | 7.47 |
| CHEMBL220492 | TOPIRAMATE | 4.0 | 1 | 7.42 |
| CHEMBL266026 | — | — | 1 | 7.32 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.29 |
| CHEMBL6633 | — | — | 1 | 7.27 |
| CHEMBL17 | DICHLORPHENAMIDE | 4.0 | 1 | 7.21 |
| CHEMBL750 | ZONISAMIDE | 4.0 | 1 | 6.78 |
| CHEMBL328560 | SULTHIAME | 3.0 | 1 | 6.56 |
| CHEMBL220491 | BRINZOLAMIDE | 4.0 | 1 | 6.56 |
| CHEMBL218490 | DORZOLAMIDE | 4.0 | 1 | 6.55 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 6.49 |
| CHEMBL265674 | — | — | 1 | 6.43 |
| CHEMBL26 | SULPIRIDE | 3.0 | 1 | 6.42 |
| CHEMBL6753 | — | — | 1 | 6.41 |
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 6.41 |
| CHEMBL435 | HYDROCHLOROTHIAZIDE | 4.0 | 1 | 6.41 |
| CHEMBL77517 | INDISULAM | 2.0 | 1 | 6.37 |
| CHEMBL865 | VALDECOXIB | 4.0 | 1 | 6.29 |
| CHEMBL418 | 2,4-DISULFAMYLTRIFLUOROMETHYLANILINE | — | 1 | 6.26 |
| CHEMBL574 | P-TOLUENESULFONAMIDE | 3.0 | 1 | 6.17 |
| CHEMBL7087 | — | — | 1 | 6.15 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 6.13 |
| CHEMBL310671 | SACCHARIN | 3.0 | 1 | 6.12 |
| CHEMBL360356 | — | — | 1 | 6.10 |
| CHEMBL266240 | — | — | 1 | 6.09 |
| CHEMBL6685 | — | — | 1 | 6.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL71611 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL268439 | — | Ki | = | 3.9 | nM | 8.41 |
| CHEMBL7146 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL73962 | BENZOLAMIDE | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL51668 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL220492 | TOPIRAMATE | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL266026 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL6633 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | = | 62.0 | nM | 7.21 |
| CHEMBL750 | ZONISAMIDE | Ki | = | 165.0 | nM | 6.78 |
| CHEMBL220491 | BRINZOLAMIDE | Ki | = | 278.0 | nM | 6.56 |
| CHEMBL328560 | SULTHIAME | Ki | = | 276.0 | nM | 6.56 |
| CHEMBL218490 | DORZOLAMIDE | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 326.0 | nM | 6.49 |
| CHEMBL265674 | — | Ki | = | 370.0 | nM | 6.43 |
| CHEMBL26 | SULPIRIDE | Ki | = | 378.0 | nM | 6.42 |
| CHEMBL6753 | — | Ki | = | 393.0 | nM | 6.41 |
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 387.0 | nM | 6.41 |
| CHEMBL435 | HYDROCHLOROTHIAZIDE | Ki | = | 394.0 | nM | 6.41 |
| CHEMBL77517 | INDISULAM | Ki | = | 423.0 | nM | 6.37 |
| CHEMBL865 | VALDECOXIB | Ki | = | 517.0 | nM | 6.29 |
| CHEMBL418 | 2,4-DISULFAMYLTRIFLUOROMETHYLANILINE | Ki | = | 552.0 | nM | 6.26 |
| CHEMBL574 | P-TOLUENESULFONAMIDE | Ki | = | 675.0 | nM | 6.17 |
| CHEMBL7087 | — | Ki | = | 715.0 | nM | 6.15 |
| CHEMBL118 | CELECOXIB | Ki | = | 732.0 | nM | 6.13 |
| CHEMBL310671 | SACCHARIN | Ki | = | 751.0 | nM | 6.12 |
| CHEMBL360356 | — | Ki | = | 792.0 | nM | 6.10 |
| CHEMBL266240 | — | Ki | = | 820.0 | nM | 6.09 |
| CHEMBL6685 | — | Ki | = | 866.0 | nM | 6.06 |
| CHEMBL67755 | — | Ki | = | 879.0 | nM | 6.06 |
| CHEMBL6853 | — | Ki | = | 890.0 | nM | 6.05 |
| CHEMBL7092 | — | Ki | = | 884.0 | nM | 6.05 |
| CHEMBL306195 | — | Ki | = | 965.0 | nM | 6.01 |
| CHEMBL419 | MAFENIDE | Ki | = | 973.0 | nM | 6.01 |
| CHEMBL414 | CARZENIDE | Ki | = | 1215.0 | nM | 5.92 |
| CHEMBL6784 | — | Ki | = | 1380.0 | nM | 5.86 |
| CHEMBL6919 | — | Ki | = | 4260.0 | nM | 5.37 |
| CHEMBL7204 | — | Ki | = | 6081.0 | nM | 5.22 |
| CHEMBL6705 | — | Ki | = | 7750.0 | nM | 5.11 |
| CHEMBL21 | SULFANILAMIDE | Ki | = | 7700.0 | nM | 5.11 |
| CHEMBL176495 | — | Ki | = | 8850.0 | nM | 5.05 |