Assay Detail
Binding
CHEMBL1947453
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Clostridium perfringens ATCC 10543 sialidase Nan1 c-terminal catalytic domain using 4-methylumbelliferyl-alpha-D-N-acetylneuraminic acid sodium salt hydrate as substrate by fluorimetric analysis
18
Total Activities
9
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Clostridium perfringens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Selective and slow-binding inhibition of shikonin derivatives isolated from Lithospermum erythrorhizon on glycosyl hydrolase 33 and 34 sialidases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.56 | 6.70 |
| Inhibition | 9 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1944654 | SHIKONOFURAN E | — | 2 | 6.70 |
| CHEMBL1946217 | SHIKONOFURAN C | — | 2 | 6.22 |
| CHEMBL1946216 | SHIKONOFURAN D | — | 2 | 6.00 |
| CHEMBL267024 | DIMETHYLACRYLSHIKONIN | — | 2 | 5.72 |
| CHEMBL403516 | ACETYLSHIKONIN | — | 2 | 5.60 |
| CHEMBL9416 | ISOBUTYLSHIKONIN | — | 2 | 5.54 |
| CHEMBL397309 | BETA-HYDROXYISOVALERYLSHIKONIN | — | 2 | 5.47 |
| CHEMBL486627 | DEOXYSHIKONIN | — | 2 | 4.56 |
| CHEMBL9470 | SHIKONIN | — | 2 | 4.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1944654 | SHIKONOFURAN E | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1946217 | SHIKONOFURAN C | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL1946216 | SHIKONOFURAN D | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL267024 | DIMETHYLACRYLSHIKONIN | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL403516 | ACETYLSHIKONIN | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL9416 | ISOBUTYLSHIKONIN | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL397309 | BETA-HYDROXYISOVALERYLSHIKONIN | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL486627 | DEOXYSHIKONIN | IC50 | = | 27500.0 | nM | 4.56 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 53800.0 | nM | 4.27 |
| CHEMBL9470 | SHIKONIN | Inhibition | - | % | - | |
| CHEMBL403516 | ACETYLSHIKONIN | Inhibition | - | % | - | |
| CHEMBL267024 | DIMETHYLACRYLSHIKONIN | Inhibition | - | % | - | |
| CHEMBL397309 | BETA-HYDROXYISOVALERYLSHIKONIN | Inhibition | - | % | - | |
| CHEMBL9416 | ISOBUTYLSHIKONIN | Inhibition | - | % | - | |
| CHEMBL486627 | DEOXYSHIKONIN | Inhibition | - | % | - | |
| CHEMBL1946216 | SHIKONOFURAN D | Inhibition | - | % | - | |
| CHEMBL1944654 | SHIKONOFURAN E | Inhibition | - | % | - | |
| CHEMBL1946217 | SHIKONOFURAN C | Inhibition | - | % | - |