Assay Detail
Binding
CHEMBL1947481
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]iodomelatonin form human MT1 receptor expressed in CHO cells after 120 mins
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, synthesis and pharmacological evaluation of new series of naphthalenic analogues as melatoninergic (MT1/MT2) and serotoninergic 5-HT2C dual ligands (I).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 29 | 8.33 | 10.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1946221 | — | — | 1 | 10.52 |
| CHEMBL1946224 | — | — | 1 | 10.22 |
| CHEMBL1946220 | — | — | 1 | 10.15 |
| CHEMBL10878 | AGOMELATINE | 4.0 | 1 | 10.00 |
| CHEMBL1946232 | — | — | 1 | 10.00 |
| CHEMBL1946233 | — | — | 1 | 9.82 |
| CHEMBL1946234 | — | — | 1 | 9.77 |
| CHEMBL139410 | — | — | 1 | 9.41 |
| CHEMBL1946705 | — | — | 1 | 8.77 |
| CHEMBL1946708 | — | — | 1 | 8.76 |
| CHEMBL1946231 | — | — | 1 | 8.64 |
| CHEMBL342432 | — | — | 1 | 8.41 |
| CHEMBL1946709 | — | — | 1 | 8.40 |
| CHEMBL1946228 | — | — | 1 | 8.38 |
| CHEMBL1946229 | — | — | 1 | 8.36 |
| CHEMBL1946222 | — | — | 1 | 8.35 |
| CHEMBL1946707 | — | — | 1 | 8.28 |
| CHEMBL1946706 | — | — | 1 | 8.25 |
| CHEMBL1946235 | — | — | 1 | 8.21 |
| CHEMBL1946704 | — | — | 1 | 8.11 |
| CHEMBL1946702 | — | — | 1 | 7.35 |
| CHEMBL138201 | — | — | 1 | 7.30 |
| CHEMBL1946225 | — | — | 1 | 7.19 |
| CHEMBL1946236 | — | — | 1 | 7.15 |
| CHEMBL1946226 | — | — | 1 | 7.14 |
| CHEMBL1946227 | — | — | 1 | 6.92 |
| CHEMBL1946223 | — | — | 1 | 6.66 |
| CHEMBL1946703 | — | — | 1 | 5.81 |
| CHEMBL1946230 | — | — | 1 | 5.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1946221 | — | Ki | = | 0.03 | nM | 10.52 |
| CHEMBL1946224 | — | Ki | = | 0.06 | nM | 10.22 |
| CHEMBL1946220 | — | Ki | = | 0.07 | nM | 10.15 |
| CHEMBL10878 | AGOMELATINE | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL1946232 | — | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL1946233 | — | Ki | = | 0.15 | nM | 9.82 |
| CHEMBL1946234 | — | Ki | = | 0.17 | nM | 9.77 |
| CHEMBL139410 | — | Ki | = | 0.39 | nM | 9.41 |
| CHEMBL1946705 | — | Ki | = | 1.71 | nM | 8.77 |
| CHEMBL1946708 | — | Ki | = | 1.73 | nM | 8.76 |
| CHEMBL1946231 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL342432 | — | Ki | = | 3.9 | nM | 8.41 |
| CHEMBL1946709 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL1946228 | — | Ki | = | 4.2 | nM | 8.38 |
| CHEMBL1946229 | — | Ki | = | 4.35 | nM | 8.36 |
| CHEMBL1946222 | — | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL1946707 | — | Ki | = | 5.24 | nM | 8.28 |
| CHEMBL1946706 | — | Ki | = | 5.58 | nM | 8.25 |
| CHEMBL1946235 | — | Ki | = | 6.1 | nM | 8.21 |
| CHEMBL1946704 | — | Ki | = | 7.74 | nM | 8.11 |
| CHEMBL1946702 | — | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL138201 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL1946225 | — | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL1946236 | — | Ki | = | 71.0 | nM | 7.15 |
| CHEMBL1946226 | — | Ki | = | 72.0 | nM | 7.14 |
| CHEMBL1946227 | — | Ki | = | 119.0 | nM | 6.92 |
| CHEMBL1946223 | — | Ki | = | 218.0 | nM | 6.66 |
| CHEMBL1946703 | — | Ki | = | 1560.0 | nM | 5.81 |
| CHEMBL1946230 | — | Ki | = | 4170.0 | nM | 5.38 |