Assay Detail
Functional
CHEMBL1947486
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, synthesis and pharmacological evaluation of new series of naphthalenic analogues as melatoninergic (MT1/MT2) and serotoninergic 5-HT2C dual ligands (I).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 7.70 | 10.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1946221 | — | — | 1 | 10.22 |
| CHEMBL1946233 | — | — | 1 | 9.02 |
| CHEMBL10878 | AGOMELATINE | 4.0 | 1 | 8.89 |
| CHEMBL1946220 | — | — | 1 | 8.75 |
| CHEMBL1946222 | — | — | 1 | 8.10 |
| CHEMBL1946235 | — | — | 1 | 7.85 |
| CHEMBL1946708 | — | — | 1 | 7.68 |
| CHEMBL342432 | — | — | 1 | 7.56 |
| CHEMBL1946709 | — | — | 1 | 7.50 |
| CHEMBL1946228 | — | — | 1 | 7.18 |
| CHEMBL1946227 | — | — | 1 | 6.73 |
| CHEMBL1946225 | — | — | 1 | 6.70 |
| CHEMBL1946236 | — | — | 1 | 6.64 |
| CHEMBL1946226 | — | — | 1 | 6.57 |
| CHEMBL1946223 | — | — | 1 | 6.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1946221 | — | EC50 | = | 0.06 | nM | 10.22 |
| CHEMBL1946233 | — | EC50 | = | 0.96 | nM | 9.02 |
| CHEMBL10878 | AGOMELATINE | EC50 | = | 1.29 | nM | 8.89 |
| CHEMBL1946220 | — | EC50 | = | 1.79 | nM | 8.75 |
| CHEMBL1946222 | — | EC50 | = | 8.01 | nM | 8.10 |
| CHEMBL1946235 | — | EC50 | = | 14.2 | nM | 7.85 |
| CHEMBL1946708 | — | EC50 | = | 21.1 | nM | 7.68 |
| CHEMBL342432 | — | EC50 | = | 27.8 | nM | 7.56 |
| CHEMBL1946709 | — | EC50 | = | 31.8 | nM | 7.50 |
| CHEMBL1946228 | — | EC50 | = | 65.6 | nM | 7.18 |
| CHEMBL1946227 | — | EC50 | = | 185.0 | nM | 6.73 |
| CHEMBL1946225 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1946236 | — | EC50 | = | 227.0 | nM | 6.64 |
| CHEMBL1946226 | — | EC50 | = | 272.0 | nM | 6.57 |
| CHEMBL1946223 | — | EC50 | = | 789.0 | nM | 6.10 |