Assay Detail
Functional
CHEMBL1947488
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human MT2 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, synthesis and pharmacological evaluation of new series of naphthalenic analogues as melatoninergic (MT1/MT2) and serotoninergic 5-HT2C dual ligands (I).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 8.94 | 10.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1946221 | — | — | 1 | 10.40 |
| CHEMBL1946233 | — | — | 1 | 10.30 |
| CHEMBL1946220 | — | — | 1 | 9.60 |
| CHEMBL1946226 | — | — | 1 | 9.51 |
| CHEMBL342432 | — | — | 1 | 9.44 |
| CHEMBL1946708 | — | — | 1 | 8.94 |
| CHEMBL1946227 | — | — | 1 | 8.76 |
| CHEMBL1946222 | — | — | 1 | 8.71 |
| CHEMBL1946235 | — | — | 1 | 8.67 |
| CHEMBL10878 | AGOMELATINE | 4.0 | 1 | 8.56 |
| CHEMBL1946225 | — | — | 1 | 8.35 |
| CHEMBL1946236 | — | — | 1 | 8.35 |
| CHEMBL1946709 | — | — | 1 | 8.31 |
| CHEMBL1946223 | — | — | 1 | 8.19 |
| CHEMBL1946228 | — | — | 1 | 8.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1946221 | — | EC50 | = | 0.04 | nM | 10.40 |
| CHEMBL1946233 | — | EC50 | = | 0.05 | nM | 10.30 |
| CHEMBL1946220 | — | EC50 | = | 0.25 | nM | 9.60 |
| CHEMBL1946226 | — | EC50 | = | 0.31 | nM | 9.51 |
| CHEMBL342432 | — | EC50 | = | 0.36 | nM | 9.44 |
| CHEMBL1946708 | — | EC50 | = | 1.14 | nM | 8.94 |
| CHEMBL1946227 | — | EC50 | = | 1.72 | nM | 8.76 |
| CHEMBL1946222 | — | EC50 | = | 1.96 | nM | 8.71 |
| CHEMBL1946235 | — | EC50 | = | 2.12 | nM | 8.67 |
| CHEMBL10878 | AGOMELATINE | EC50 | = | 2.72 | nM | 8.56 |
| CHEMBL1946225 | — | EC50 | = | 4.5 | nM | 8.35 |
| CHEMBL1946236 | — | EC50 | = | 4.51 | nM | 8.35 |
| CHEMBL1946709 | — | EC50 | = | 4.93 | nM | 8.31 |
| CHEMBL1946223 | — | EC50 | = | 6.43 | nM | 8.19 |
| CHEMBL1946228 | — | EC50 | = | 9.36 | nM | 8.03 |