Assay Detail
Binding
CHEMBL1947490
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]mesulergine from human 5HT2C receptor expressed in CHO cells after 60 mins
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and pharmacological evaluation of new series of naphthalenic analogues as melatoninergic (MT1/MT2) and serotoninergic 5-HT2C dual ligands (I).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.35 | 6.84 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1946234 | — | — | 1 | 6.84 |
| CHEMBL342432 | — | — | 1 | 6.41 |
| CHEMBL10878 | AGOMELATINE | 4.0 | 1 | 6.15 |
| CHEMBL1946233 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1946234 | — | Ki | = | 144.0 | nM | 6.84 |
| CHEMBL342432 | — | Ki | = | 391.0 | nM | 6.41 |
| CHEMBL10878 | AGOMELATINE | Ki | = | 708.0 | nM | 6.15 |
| CHEMBL1946233 | — | Ki | = | 1000.0 | nM | 6.00 |