Assay Detail
Binding
CHEMBL1947640
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Inhibition of human recombinant MAOB using kynuramine as substrate by fluorimetry
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A scaffold hopping approach to identify novel monoamine oxidase B inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.97 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1946826 | — | — | 1 | 7.00 |
| CHEMBL1946643 | — | — | 1 | 6.64 |
| CHEMBL1946828 | — | — | 1 | 6.62 |
| CHEMBL596254 | — | — | 1 | 6.52 |
| CHEMBL1946644 | — | — | 1 | 6.04 |
| CHEMBL1477100 | — | — | 1 | 5.58 |
| CHEMBL1946827 | — | — | 1 | 5.47 |
| CHEMBL1172318 | — | — | 1 | 4.94 |
| CHEMBL3145271 | — | — | 1 | 4.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1946826 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL1946643 | — | IC50 | = | 228.0 | nM | 6.64 |
| CHEMBL1946828 | — | IC50 | = | 242.0 | nM | 6.62 |
| CHEMBL596254 | — | IC50 | = | 305.0 | nM | 6.52 |
| CHEMBL1946644 | — | IC50 | = | 921.0 | nM | 6.04 |
| CHEMBL1477100 | — | IC50 | = | 2620.0 | nM | 5.58 |
| CHEMBL1946827 | — | IC50 | = | 3350.0 | nM | 5.47 |
| CHEMBL1172318 | — | IC50 | = | 11550.0 | nM | 4.94 |
| CHEMBL3145271 | — | IC50 | = | 13320.0 | nM | 4.88 |