Assay Detail
Binding
CHEMBL1947641
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Inhibition of human recombinant MAOA using kynuramine as substrate by fluorimetry
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A scaffold hopping approach to identify novel monoamine oxidase B inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.36 | 6.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1946826 | — | — | 1 | 6.57 |
| CHEMBL596254 | — | — | 1 | 6.15 |
| CHEMBL1946828 | — | — | 1 | 6.01 |
| CHEMBL1946644 | — | — | 1 | 5.27 |
| CHEMBL1172318 | — | — | 1 | 4.75 |
| CHEMBL1946827 | — | — | 1 | 4.40 |
| CHEMBL1946643 | — | — | 1 | 4.36 |
| CHEMBL1477100 | — | — | 1 | - |
| CHEMBL3145271 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1946826 | — | IC50 | = | 268.0 | nM | 6.57 |
| CHEMBL596254 | — | IC50 | = | 709.0 | nM | 6.15 |
| CHEMBL1946828 | — | IC50 | = | 979.0 | nM | 6.01 |
| CHEMBL1946644 | — | IC50 | = | 5360.0 | nM | 5.27 |
| CHEMBL1172318 | — | IC50 | = | 17700.0 | nM | 4.75 |
| CHEMBL1946827 | — | IC50 | = | 40200.0 | nM | 4.40 |
| CHEMBL1946643 | — | IC50 | = | 43460.0 | nM | 4.36 |
| CHEMBL1477100 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3145271 | — | IC50 | > | 100000.0 | nM | - |