Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL1947793

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of radiolabeled Prazosin from alpha1D adrenoceptor
36
Total Activities
36
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Alpha-1D adrenergic receptor (CHEMBL223)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

From libraries to candidate: the discovery of new ultra long-acting dibasic β₂-adrenoceptor agonists.
Alcaraz L, Bailey A, Cadogan E, Connolly S, Jewell R, Jordan S, Kindon N, Lister A, Lawson M, Mullen A, Dainty I, Nicholls D, Paine S, Pairaudeau G, Stocks MJ, Thorne P, Young A.
Bioorg Med Chem Lett (2012) 22 : 689 -695
PubMed 22079756 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 35 6.99 8.10
pIC50 1 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1944694 1 8.10
CHEMBL1944695 1 7.90
CHEMBL1945299 1 7.60
CHEMBL1945298 1 7.60
CHEMBL1945034 1 7.60
CHEMBL1945290 1 7.50
CHEMBL1945036 1 7.50
CHEMBL1945297 1 7.40
CHEMBL1945296 1 7.40
CHEMBL1944690 1 7.30
CHEMBL1944692 1 7.30
CHEMBL1947157 1 7.20
CHEMBL1944693 1 7.10
CHEMBL1945042 1 7.10
CHEMBL1945504 1 7.10
CHEMBL1944689 1 7.10
CHEMBL1945040 1 7.00
CHEMBL1945044 1 7.00
CHEMBL1945032 1 7.00
CHEMBL1944691 1 6.90
CHEMBL1945041 1 6.80
CHEMBL1945037 1 6.80
CHEMBL1945289 1 6.80
CHEMBL1945039 1 6.70
CHEMBL1945033 1 6.70
CHEMBL1945035 1 6.70
CHEMBL1945291 1 6.60
CHEMBL1945038 1 6.60
CHEMBL1945043 1 6.50
CHEMBL1945031 1 6.40

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1944694 IC50 = 7.943 nM 8.10
CHEMBL1944695 IC50 = 12.59 nM 7.90
CHEMBL1945299 IC50 = 25.12 nM 7.60
CHEMBL1945298 IC50 = 25.12 nM 7.60
CHEMBL1945034 IC50 = 25.12 nM 7.60
CHEMBL1945290 IC50 = 31.62 nM 7.50
CHEMBL1945036 IC50 = 31.62 nM 7.50
CHEMBL1945297 IC50 = 39.81 nM 7.40
CHEMBL1945296 IC50 = 39.81 nM 7.40
CHEMBL1944690 IC50 = 50.12 nM 7.30
CHEMBL1944692 IC50 = 50.12 nM 7.30
CHEMBL1947157 IC50 = 63.1 nM 7.20
CHEMBL1944689 IC50 = 79.43 nM 7.10
CHEMBL1945504 IC50 = 79.43 nM 7.10
CHEMBL1945042 IC50 = 79.43 nM 7.10
CHEMBL1944693 IC50 = 79.43 nM 7.10
CHEMBL1945032 IC50 = 100.0 nM 7.00
CHEMBL1945040 IC50 = 100.0 nM 7.00
CHEMBL1945044 IC50 = 100.0 nM 7.00
CHEMBL1944691 IC50 = 125.89 nM 6.90
CHEMBL1945041 IC50 = 158.49 nM 6.80
CHEMBL1945037 IC50 = 158.49 nM 6.80
CHEMBL1945289 IC50 = 158.49 nM 6.80
CHEMBL1945039 IC50 = 199.53 nM 6.70
CHEMBL1945033 IC50 = 199.53 nM 6.70
CHEMBL1945035 IC50 = 199.53 nM 6.70
CHEMBL1945291 IC50 = 251.19 nM 6.60
CHEMBL1945038 IC50 = 251.19 nM 6.60
CHEMBL1945043 IC50 = 316.23 nM 6.50
CHEMBL1945031 IC50 = 398.11 nM 6.40
CHEMBL1945503 IC50 = 398.11 nM 6.40
CHEMBL1945292 IC50 = 501.19 nM 6.30
CHEMBL1945300 IC50 = 501.19 nM 6.30
CHEMBL1945293 IC50 = 630.96 nM 6.20
CHEMBL1945294 IC50 = 1000.0 nM 6.00
CHEMBL1945295 pIC50 - -