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Assay Detail

CHEMBL1947794

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of radiolabeled spiperone from dopamine D2 receptor
ChEMBL ↗
36
Total Activities
36
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

D(2) dopamine receptor (CHEMBL217) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

From libraries to candidate: the discovery of new ultra long-acting dibasic β₂-adrenoceptor agonists.
Alcaraz L, Bailey A, Cadogan E, Connolly S, Jewell R, Jordan S, Kindon N, Lister A, Lawson M, Mullen A, Dainty I, Nicholls D, Paine S, Pairaudeau G, Stocks MJ, Thorne P, Young A.
Bioorg Med Chem Lett (2012) 22 : 689 -695
PubMed 22079756 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 35 6.08 7.10
pIC50 1 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1945296 — — 1 7.10
CHEMBL1945297 — — 1 6.90
CHEMBL1945041 — — 1 6.60
CHEMBL1947157 — — 1 6.60
CHEMBL1945037 — — 1 6.50
CHEMBL1944691 — — 1 6.40
CHEMBL1945298 — — 1 6.40
CHEMBL1945031 — — 1 6.40
CHEMBL1944694 — — 1 6.20
CHEMBL1945042 — — 1 6.20
CHEMBL1944690 — — 1 6.20
CHEMBL1945292 — — 1 6.10
CHEMBL1945035 — — 1 6.10
CHEMBL1945289 — — 1 6.10
CHEMBL1945044 — — 1 6.10
CHEMBL1945299 — — 1 6.00
CHEMBL1945039 — — 1 6.00
CHEMBL1944689 — — 1 6.00
CHEMBL1945291 — — 1 6.00
CHEMBL1945290 — — 1 5.90
CHEMBL1945033 — — 1 5.80
CHEMBL1945504 — — 1 5.70
CHEMBL1944692 — — 1 5.70
CHEMBL1944695 — — 1 5.70
CHEMBL1945034 — — 1 5.60
CHEMBL1945036 — — 1 5.60
CHEMBL1945040 — — 1 5.60
CHEMBL1945294 — — 1 5.50
CHEMBL1945043 — — 1 5.30
CHEMBL1945293 — — 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1945296 — IC50 = 79.43 nM 7.10
CHEMBL1945297 — IC50 = 125.89 nM 6.90
CHEMBL1945041 — IC50 = 251.19 nM 6.60
CHEMBL1947157 — IC50 = 251.19 nM 6.60
CHEMBL1945037 — IC50 = 316.23 nM 6.50
CHEMBL1944691 — IC50 = 398.11 nM 6.40
CHEMBL1945298 — IC50 = 398.11 nM 6.40
CHEMBL1945031 — IC50 = 398.11 nM 6.40
CHEMBL1944694 — IC50 = 630.96 nM 6.20
CHEMBL1945042 — IC50 = 630.96 nM 6.20
CHEMBL1944690 — IC50 = 630.96 nM 6.20
CHEMBL1945292 — IC50 = 794.33 nM 6.10
CHEMBL1945035 — IC50 = 794.33 nM 6.10
CHEMBL1945289 — IC50 = 794.33 nM 6.10
CHEMBL1945044 — IC50 = 794.33 nM 6.10
CHEMBL1945039 — IC50 = 1000.0 nM 6.00
CHEMBL1944689 — IC50 = 1000.0 nM 6.00
CHEMBL1945299 — IC50 = 1000.0 nM 6.00
CHEMBL1945291 — IC50 = 1000.0 nM 6.00
CHEMBL1945290 — IC50 = 1258.93 nM 5.90
CHEMBL1945033 — IC50 = 1584.89 nM 5.80
CHEMBL1945504 — IC50 = 1995.26 nM 5.70
CHEMBL1944692 — IC50 = 1995.26 nM 5.70
CHEMBL1944695 — IC50 = 1995.26 nM 5.70
CHEMBL1945040 — IC50 = 2511.89 nM 5.60
CHEMBL1945036 — IC50 = 2511.89 nM 5.60
CHEMBL1945034 — IC50 = 2511.89 nM 5.60
CHEMBL1945294 — IC50 = 3162.28 nM 5.50
CHEMBL1945043 — IC50 = 5011.87 nM 5.30
CHEMBL1945293 — IC50 > 10000.0 nM -
CHEMBL1945295 — pIC50 - — -
CHEMBL1945032 — IC50 > 794.33 nM -
CHEMBL1945038 — IC50 > 2511.89 nM -
CHEMBL1944693 — IC50 > 794.33 nM -
CHEMBL1945300 — IC50 > 7943.28 nM -
CHEMBL1945503 — IC50 > 10000.0 nM -