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Assay Detail

CHEMBL1947809

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to Alpha-1D adrenoceptor expressed in HEK cells by calcium flux assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Cell Type HEK293
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Alpha-1D adrenergic receptor (CHEMBL223)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

From libraries to candidate: the discovery of new ultra long-acting dibasic β₂-adrenoceptor agonists.
Alcaraz L, Bailey A, Cadogan E, Connolly S, Jewell R, Jordan S, Kindon N, Lister A, Lawson M, Mullen A, Dainty I, Nicholls D, Paine S, Pairaudeau G, Stocks MJ, Thorne P, Young A.
Bioorg Med Chem Lett (2012) 22 : 689 -695
PubMed 22079756 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 1 6.90 6.90

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1945039 1 6.90

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1945039 EC50 = 125.89 nM 6.90