Assay Detail
Functional
CHEMBL1947834
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Partial agonist activity at human PPARgamma LBD assessed as activation of PGC1 by HTRF assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Peroxisome proliferator-activated receptor gamma (CHEMBL235) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Benzimidazolones: a new class of selective peroxisome proliferator-activated receptor γ (PPARγ) modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 7.80 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1946409 | — | — | 1 | 9.00 |
| CHEMBL1947143 | — | — | 1 | 8.70 |
| CHEMBL1947147 | — | — | 1 | 8.70 |
| CHEMBL107367 | FARGLITAZAR | 2.0 | 1 | 8.40 |
| CHEMBL461571 | — | — | 1 | 8.30 |
| CHEMBL562864 | — | — | 1 | 8.30 |
| CHEMBL1947146 | — | — | 1 | 8.10 |
| CHEMBL1947144 | — | — | 1 | 7.54 |
| CHEMBL121 | ROSIGLITAZONE | 4.0 | 1 | 6.96 |
| CHEMBL1946568 | — | — | 1 | 6.34 |
| CHEMBL1946570 | — | — | 1 | 5.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1946409 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1947143 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1947147 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL107367 | FARGLITAZAR | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL461571 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL562864 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1947146 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1947144 | — | EC50 | = | 29.0 | nM | 7.54 |
| CHEMBL121 | ROSIGLITAZONE | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL1946568 | — | EC50 | = | 460.0 | nM | 6.34 |
| CHEMBL1946570 | — | EC50 | = | 3240.0 | nM | 5.49 |