Assay Detail
Binding
CHEMBL1947992
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Inhibition of guinea pig ENaCbeta1/gamma1 expressed in FRT cells by short-circuit current technique
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Cell Type | FRT |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of a novel chemotype of potent human ENaC blockers using a bioisostere approach. Part 1: quaternary amines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.51 | 6.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1944743 | — | — | 1 | 6.75 |
| CHEMBL945 | AMILORIDE | 4.0 | 1 | 6.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1944743 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL945 | AMILORIDE | IC50 | = | 540.0 | nM | 6.27 |