Assay Detail
Functional
CHEMBL1948064
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of protein synthesis using Escherichia coli S30 extracts preincubated for 10 mins measured after 50 mins by luciferase reporter gene assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Escherichia coli |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of 4''-ether linked azithromycin-quinolone hybrid series: influence of the central linker on the antibacterial activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.55 | 6.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1136 | TELITHROMYCIN | 4.0 | 1 | 6.64 |
| CHEMBL1945161 | — | — | 1 | 6.55 |
| CHEMBL1945693 | — | — | 1 | 6.46 |
| CHEMBL8 | CIPROFLOXACIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1136 | TELITHROMYCIN | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL1945161 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL1945693 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL8 | CIPROFLOXACIN | IC50 | > | 50000.0 | nM | - |