Assay Detail
Binding
CHEMBL1948065
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Inhibition of Escherichia coli DNA gyrase-mediated supercoiling of relaxed pBR322 DNA
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of 4''-ether linked azithromycin-quinolone hybrid series: influence of the central linker on the antibacterial activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.83 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8 | CIPROFLOXACIN | 4.0 | 1 | 6.10 |
| CHEMBL1945693 | — | — | 1 | 4.22 |
| CHEMBL1945161 | — | — | 1 | 4.16 |
| CHEMBL1136 | TELITHROMYCIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8 | CIPROFLOXACIN | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL1945693 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL1945161 | — | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL1136 | TELITHROMYCIN | IC50 | > | 50000.0 | nM | - |