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Assay Detail

CHEMBL1948175

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to chicken riboflavin binding protein assessed as dissociation constant at pH 4 in 0.1 M NaAc by isothermal titration calorimetric assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Gallus gallus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Riboflavin-binding protein (CHEMBL1944489)
Type SINGLE PROTEIN
Organism Gallus gallus

Publication

Bioanalytical Screening of Riboflavin Antagonists for Targeted Drug Delivery - A Thermodynamic and Kinetic Study.
Plantinga A, Witte A, Li MH, Harmon A, Choi SK, Banaszak Holl MM, Orr BG, Baker JR, Sinniah K.
ACS Med Chem Lett (2011) 2 : 363 -367
PubMed 21686082 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 1 7.34 7.34

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1534 RIBOFLAVIN 4.0 1 7.34

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1534 RIBOFLAVIN Kd = 46.0 nM 7.34