Assay Detail
Binding
CHEMBL1948264
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Inhibition of wild-type B-Raf
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase B-raf (CHEMBL5145) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Small molecule inhibitors of BRAF in clinical trials.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.99 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1946171 | — | — | 1 | 8.52 |
| CHEMBL1230020 | PLX-4720 | — | 1 | 7.89 |
| CHEMBL1946170 | REGORAFENIB | 4.0 | 1 | 7.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1946171 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1230020 | PLX-4720 | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1946170 | REGORAFENIB | IC50 | = | 28.0 | nM | 7.55 |