Assay Detail
Binding
CHEMBL1948414
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]epibatidine from Aplysia californica acetylcholine binding protein expressed using baculoviral system after 1.5 hrs by scintillation counting
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Aplysia californica |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Soluble acetylcholine receptor (CHEMBL1944497) ↗| Type | SINGLE PROTEIN |
| Organism | Aplysia californica |
Publication
Structure-based design, synthesis and structure-activity relationships of dibenzosuberyl- and benzoate-substituted tropines as ligands for acetylcholine-binding protein.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 26 | 5.81 | 8.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL122270 | LOBELINE | 2.0 | 1 | 8.60 |
| CHEMBL1947053 | — | — | 1 | 7.50 |
| CHEMBL1947058 | — | — | 1 | 7.00 |
| CHEMBL1947056 | — | — | 1 | 6.80 |
| CHEMBL1947055 | — | — | 1 | 6.80 |
| CHEMBL1947206 | — | — | 1 | 6.70 |
| CHEMBL1946189 | — | — | 1 | 6.20 |
| CHEMBL1947061 | — | — | 1 | 6.20 |
| CHEMBL1947060 | — | — | 1 | 6.10 |
| CHEMBL1947057 | — | — | 1 | 6.10 |
| CHEMBL1946187 | — | — | 1 | 6.00 |
| CHEMBL1947054 | — | — | 1 | 6.00 |
| CHEMBL1947059 | — | — | 1 | 5.70 |
| CHEMBL3 | NICOTINE | 4.0 | 1 | 5.60 |
| CHEMBL1947051 | BENZOYL TROPINE | — | 1 | 5.40 |
| CHEMBL1947049 | — | — | 1 | 5.30 |
| CHEMBL1946186 | DEPTROPINE | 2.0 | 1 | 5.20 |
| CHEMBL1947062 | — | — | 1 | 5.10 |
| CHEMBL1794606 | — | — | 1 | 5.00 |
| CHEMBL1946188 | — | — | 1 | 5.00 |
| CHEMBL1946185 | — | — | 1 | 5.00 |
| CHEMBL1947047 | — | — | 1 | 4.90 |
| CHEMBL1947052 | — | — | 1 | 4.80 |
| CHEMBL1947050 | — | — | 1 | 4.80 |
| CHEMBL1947205 | — | — | 1 | 4.70 |
| CHEMBL1947048 | — | — | 1 | 4.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL122270 | LOBELINE | Ki | = | 2.512 | nM | 8.60 |
| CHEMBL1947053 | — | Ki | = | 31.62 | nM | 7.50 |
| CHEMBL1947058 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL1947056 | — | Ki | = | 158.49 | nM | 6.80 |
| CHEMBL1947055 | — | Ki | = | 158.49 | nM | 6.80 |
| CHEMBL1947206 | — | Ki | = | 199.53 | nM | 6.70 |
| CHEMBL1946189 | — | Ki | = | 630.96 | nM | 6.20 |
| CHEMBL1947061 | — | Ki | = | 630.96 | nM | 6.20 |
| CHEMBL1947060 | — | Ki | = | 794.33 | nM | 6.10 |
| CHEMBL1947057 | — | Ki | = | 794.33 | nM | 6.10 |
| CHEMBL1946187 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL1947054 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL1947059 | — | Ki | = | 1995.26 | nM | 5.70 |
| CHEMBL3 | NICOTINE | Ki | = | 2511.89 | nM | 5.60 |
| CHEMBL1947051 | BENZOYL TROPINE | Ki | = | 3981.07 | nM | 5.40 |
| CHEMBL1947049 | — | Ki | = | 5011.87 | nM | 5.30 |
| CHEMBL1946186 | DEPTROPINE | Ki | = | 6309.57 | nM | 5.20 |
| CHEMBL1947062 | — | Ki | = | 7943.28 | nM | 5.10 |
| CHEMBL1794606 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL1946188 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL1946185 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL1947047 | — | Ki | = | 12589.25 | nM | 4.90 |
| CHEMBL1947052 | — | Ki | = | 15848.93 | nM | 4.80 |
| CHEMBL1947050 | — | Ki | = | 15848.93 | nM | 4.80 |
| CHEMBL1947205 | — | Ki | = | 19952.62 | nM | 4.70 |
| CHEMBL1947048 | — | Ki | = | 31622.78 | nM | 4.50 |