Assay Detail
Binding
CHEMBL1948547
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Inhibition of human carbonic anhydrase 2 using 4-nitrophenylacetate as substrate after 3 mins using spectrophotometry by Lineweaver-Burk plot analysis
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-activity relationships for the interaction of 5,10-dihydroindeno[1,2-b]indole derivatives with human and bovine carbonic anhydrase isoforms I, II, III, IV and VI.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 27 | 5.96 | 6.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL122708 | EMATE | — | 1 | 6.64 |
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 6.50 |
| CHEMBL594918 | — | — | 1 | 6.46 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 6.43 |
| CHEMBL596277 | — | — | 1 | 6.35 |
| CHEMBL593667 | — | — | 1 | 6.33 |
| CHEMBL1668603 | 1,2-DIMETHOXYBENZENE | — | 1 | 6.30 |
| CHEMBL593759 | — | — | 1 | 6.30 |
| CHEMBL595861 | — | — | 1 | 6.28 |
| CHEMBL607823 | — | — | 1 | 6.27 |
| CHEMBL593507 | — | — | 1 | 6.25 |
| CHEMBL610454 | — | — | 1 | 6.19 |
| CHEMBL593972 | — | — | 1 | 6.13 |
| CHEMBL611504 | — | — | 1 | 6.11 |
| CHEMBL596276 | — | — | 1 | 6.09 |
| CHEMBL750 | ZONISAMIDE | 4.0 | 1 | 5.97 |
| CHEMBL607824 | — | — | 1 | 5.71 |
| CHEMBL607813 | — | — | 1 | 5.69 |
| CHEMBL610455 | — | — | 1 | 5.67 |
| CHEMBL593037 | — | — | 1 | 5.64 |
| CHEMBL611502 | — | — | 1 | 5.64 |
| CHEMBL593276 | — | — | 1 | 5.64 |
| CHEMBL596060 | — | — | 1 | 5.63 |
| CHEMBL608978 | — | — | 1 | 5.61 |
| CHEMBL594224 | — | — | 1 | 5.60 |
| CHEMBL280998 | CATECHOL | — | 1 | 5.00 |
| CHEMBL15844 | INDOLE | — | 1 | 4.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL122708 | EMATE | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 320.0 | nM | 6.50 |
| CHEMBL594918 | — | Ki | = | 343.0 | nM | 6.46 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 370.0 | nM | 6.43 |
| CHEMBL596277 | — | Ki | = | 447.0 | nM | 6.35 |
| CHEMBL593667 | — | Ki | = | 472.0 | nM | 6.33 |
| CHEMBL1668603 | 1,2-DIMETHOXYBENZENE | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL593759 | — | Ki | = | 496.0 | nM | 6.30 |
| CHEMBL595861 | — | Ki | = | 524.0 | nM | 6.28 |
| CHEMBL607823 | — | Ki | = | 536.0 | nM | 6.27 |
| CHEMBL593507 | — | Ki | = | 561.0 | nM | 6.25 |
| CHEMBL610454 | — | Ki | = | 648.0 | nM | 6.19 |
| CHEMBL593972 | — | Ki | = | 734.0 | nM | 6.13 |
| CHEMBL611504 | — | Ki | = | 785.0 | nM | 6.11 |
| CHEMBL596276 | — | Ki | = | 813.0 | nM | 6.09 |
| CHEMBL750 | ZONISAMIDE | Ki | = | 1070.0 | nM | 5.97 |
| CHEMBL607824 | — | Ki | = | 1940.0 | nM | 5.71 |
| CHEMBL607813 | — | Ki | = | 2030.0 | nM | 5.69 |
| CHEMBL610455 | — | Ki | = | 2120.0 | nM | 5.67 |
| CHEMBL593037 | — | Ki | = | 2310.0 | nM | 5.64 |
| CHEMBL611502 | — | Ki | = | 2270.0 | nM | 5.64 |
| CHEMBL593276 | — | Ki | = | 2290.0 | nM | 5.64 |
| CHEMBL596060 | — | Ki | = | 2360.0 | nM | 5.63 |
| CHEMBL608978 | — | Ki | = | 2440.0 | nM | 5.61 |
| CHEMBL594224 | — | Ki | = | 2520.0 | nM | 5.60 |
| CHEMBL280998 | CATECHOL | Ki | = | 9900.0 | nM | 5.00 |
| CHEMBL15844 | INDOLE | Ki | = | 32500.0 | nM | 4.49 |