Assay Detail
Binding
CHEMBL1949356
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT1 receptor after 180 mins by gamma counting
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of 6-substituted aminocarbonyl benzimidazole derivatives as nonpeptidic angiotensin II AT1 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.62 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1017 | TELMISARTAN | 4.0 | 1 | 9.00 |
| CHEMBL1945010 | — | — | 1 | 8.89 |
| CHEMBL1947129 | — | — | 1 | 8.62 |
| CHEMBL1947131 | — | — | 1 | 8.37 |
| CHEMBL191 | LOSARTAN | 4.0 | 1 | 7.79 |
| CHEMBL1945006 | — | — | 1 | 7.51 |
| CHEMBL1945007 | — | — | 1 | 7.51 |
| CHEMBL1947128 | — | — | 1 | 7.28 |
| CHEMBL1945009 | — | — | 1 | 7.24 |
| CHEMBL1945148 | — | — | 1 | 6.97 |
| CHEMBL1945149 | — | — | 1 | 6.70 |
| CHEMBL1945008 | — | — | 1 | 6.67 |
| CHEMBL1947130 | — | — | 1 | 6.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1017 | TELMISARTAN | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1945010 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL1947129 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL1947131 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL191 | LOSARTAN | IC50 | = | 16.2 | nM | 7.79 |
| CHEMBL1945006 | — | IC50 | = | 30.6 | nM | 7.51 |
| CHEMBL1945007 | — | IC50 | = | 30.8 | nM | 7.51 |
| CHEMBL1947128 | — | IC50 | = | 52.5 | nM | 7.28 |
| CHEMBL1945009 | — | IC50 | = | 57.6 | nM | 7.24 |
| CHEMBL1945148 | — | IC50 | = | 106.0 | nM | 6.97 |
| CHEMBL1945149 | — | IC50 | = | 198.0 | nM | 6.70 |
| CHEMBL1945008 | — | IC50 | = | 214.0 | nM | 6.67 |
| CHEMBL1947130 | — | IC50 | = | 326.0 | nM | 6.49 |