Assay Detail
Binding
CHEMBL1949357
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of 6-substituted aminocarbonyl benzimidazole derivatives as nonpeptidic angiotensin II AT1 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.34 | 9.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1017 | TELMISARTAN | 4.0 | 1 | 9.48 |
| CHEMBL1947129 | — | — | 1 | 5.96 |
| CHEMBL1945009 | — | — | 1 | 5.92 |
| CHEMBL1945149 | — | — | 1 | 5.89 |
| CHEMBL1945010 | — | — | 1 | 5.85 |
| CHEMBL1945008 | — | — | 1 | 5.82 |
| CHEMBL1947131 | — | — | 1 | 5.44 |
| CHEMBL1947130 | — | — | 1 | - |
| CHEMBL1945006 | — | — | 1 | - |
| CHEMBL1945007 | — | — | 1 | - |
| CHEMBL1945148 | — | — | 1 | - |
| CHEMBL191 | LOSARTAN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1017 | TELMISARTAN | IC50 | = | 0.33 | nM | 9.48 |
| CHEMBL1947129 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL1945009 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL1945149 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL1945010 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL1945008 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL1947131 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL1947130 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1945006 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1945007 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1945148 | — | IC50 | - | — | - | |
| CHEMBL191 | LOSARTAN | IC50 | > | 10000.0 | nM | - |